Detroit at Minnesota 2:10 PM ET
Jackson Jobe is eager for his first big-league victory.
Philadelphia at St. Louis 2:15 PM ET
St. Louis Cardinals right-hander Miles Mikolas wants to take a clear mind to the mound when he faces the visiting Philadelphia Phillies on Saturday afternoon.
San Francisco at NY Yankees 3:05 PM ET
Hours before the San Francisco Giants continued their best start since 2003 at Yankee Stadium, manager Bob Melvin made lineup changes by moving Mike Yastrzemski up to the leadoff slot and switching LaMonte Wade Jr. from leadoff to sixth.
NY Mets at Athletics 4:05 PM ET
The New York Mets spent most of the winter preparing for life without Pete Alonso.
Toronto at Baltimore 4:05 PM ET
The Baltimore Orioles were welcoming a day off this week, yet also anxious to get back to work and fix glitches from the first couple of weeks of the season.
Atlanta at Tampa Bay 4:10 PM ET
Aiming for a series win in interleague play, the Tampa Bay Rays will look to make matters worse for the visiting Atlanta Braves on Saturday afternoon.
Washington at Miami 4:10 PM ET
Miami right-hander Sandy Alcantara will return from paternity leave to make the start on Saturday afternoon as the Marlins host the Washington Nationals in the second contest of a three-game series.
Boston at Chi. White Sox 4:10 PM ET
Losses and injuries have mounted for the Chicago White Sox in the first two weeks of the season.
Kansas City at Cleveland 6:10 PM ET
Early on, the Cleveland Guardians have had their way with the Kansas City Royals.
Pittsburgh at Cincinnati 6:40 PM ET
The Cincinnati Reds will welcome back a key component to their rotation on Saturday evening when they host the Pittsburgh Pirates in the second contest of a three-game series.
LA Angels at Houston 7:10 PM ET
Houston Astros manager Joe Espada expresses an unwavering confidence in his club, particularly when performances don't match grand expectations or past results.
Milwaukee at Arizona 8:10 PM ET
Corbin Burnes will take the mound Saturday, still trying to earn his first win since signing a six-year, $210 million free agent deal with the Arizona Diamondbacks last winter.
Colorado at San Diego 8:40 PM ET
Jake Cronenworth joined Jackson Merrill on the injured list before the San Diego Padres hosted the Colorado Rockies Friday night.
Chi. Cubs at LA Dodgers 9:10 PM ET
While the Chicago Cubs have been carving up their schedule in the early part of the season, games against the Los Angeles Dodgers have been a particular issue.
Texas at Seattle 9:40 PM ET
The Seattle Mariners received a shipment of this season's biggest fad, the "torpedo" bats, and some players tried them for the first time in batting practice Friday.